News & Latest Findings
Enrollee contributions are resulting in the latest published research in top journals. Below are some of the articles published from our findings.
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Press Releases & News Coverage
28 January 2026
Webinar: Epilepsy & Pregnancy
In Collaboration with Epilepsy Alliance America
Click Here to Watch the Recording
21 March 2005
American Academy of Neurology
Press Release
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22 March 2005
Anti-Seizure Drug Valproate Linked to Birth Defects
Daily News Central – Media Coverage
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Journal Articles
Ng, SCW, Hernandez-Diaz, S., Quinn, M., Ward, J. R., Conant, S., Lyons, A., and High, F. A.
Antiseizure Medication Polytherapies During Pregnancy and the Risk of Congenital Malformations
Neurology
2026, 106: e214984
Hernandez-Diaz, S., Quinn, M., Conant, S., Lyons, A., Paik, H., Ward, J., Bui, E., Hauser, W. A., Yerby, M., Voinescu, P. E., Hirtz, D. G., High, F. A., Holmes, L. B.
Use of Antiseizure Medications Early in Pregnancy and the Risk of Major Malformations in the Newborn
Neurology
2025; 105: e213786
Holmes, L. B., Quinn, M., Conant, S., Lyons, A., Hauser, W. A., Yerby, M., Hernandez-Diaz, S.
Ascertainment of malformations in pregnancy registries: Lessons learned in the North American AED Pregnancy Registry
Birth Defects Research
2023; 115(14):1274-1283
Toufaily, M. H., Westgate, M.-N., Lin, A. E., Holmes, L. B.
Causes of Congenital Malformations
Birth Defects Research
2018; 1 10:87-91
Holmes, L. B.
Commentary: Setting Standards for Pregnancy Registries
Drug Safety
2018; 41:7-9
Hernández-Diaz, S., McElrath, T. F., Glynn, R. J., Pennell, P. B., Hauser, W. A., Yerby, M., Holmes, L. B.
Fetal Growth and Premature Delivery in Pregnant Women on Anti-epileptic Drugs
Annals of Neurology
Accepted Article, doi: 10.1002/ana.25031
Margulis, A.V., Mittleman, M.A., Glynn, R. J., Holmes, L. B., Hernandez-Diaz, S.
Effects of Gestational Age at Enrollment in Pregnancy Exposure Registries
Pharmacoepidemiology and Drug Safety
2015; 24:343-352
Herndandez-Diaz, S., Mittendorf, R., Smith, C.R., Hauser, W.A., Yerby, M., Holmes L.B.
Association Between Topiramate and Zonisamide Use During Pregnancy and Low Birth Weight
Obstetrics & Gynecology
2014; 123(1):21-28
Herndandez-Diaz, S., Smith, C.R., Shen, A., Mittendorf, R., Hauser, W.A., Yerby, M., Holmes L.B.
Comparative Safety of Antiepileptic Drugs During Pregnancy
Neurology
2012; 78:1692-1699
Holmes, L. B., Westgate, M.N.
Using ICD-9 Codes to Establish Prevalence of Malformations in Newborn Infants
Birth Defects Research (Part A): Clinical and Molecular Teratology
2012; 94:208-214
Holmes, L. B., Westgate, M.N.
Inclusion and Exclusion Criteria for Malformations in Newborn Infants Exposed to Potential Teratogens
Birth Defects Research (Part A): Clinical and Molecular Teratology
2011; 91:807-812
Holmes L.B., Wyszynski D.F., Baldwin, E.J., Smith, C.R., Habecker, E., Glassman, L.H.
Increased Frequency for Isolated Cleft Palate Among Infants Exposed to Lamotrigine During Pregnancy
Neurology 2008; 70:2152-2158
Bromfield, E. B., Dworetzky, B. A., Wyszynski, D. F., Smith, C.R., Baldwin, E. J., Holmes, L. B.
Valproate Teratogenicity and Epilepsy Syndrome
Epilepsia 2008; 49(12):2122-2124
Wyszynksi D.F., Nambisan M., Surve T., Alsdorf R.M., Smith C.R., Holmes L.B.
Increased Rate of Major Malformations in Offspring Exposed to Valproate During Pregnancy
Neurology 2005; 64:961-965
Holmes L.B., Wyszynski D.F.
North American Antiepileptic Drug Pregnancy Registry
Epilepsia 2004; 45(11):1465
Holmes L.B., Wyszynski D.F., Lieberman E.S.
The AED (Antiepileptic Drug) Pregnancy Registry: A 6-Year Experience
Arch Neurol. 2004; 61:673-678
Abstracts & Other Texts
Smith, C.R., Holmes, L.B.
Recruitment of An Unexposed Control Group For A Pregnancy Registry
Birth Defects Research (Part A) 82:311 (2008)
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Holmes, L.B., Smith, C.R., Herndandez-Diaz, S.
Pregnancy Registries: Larger Sample Sizes Essential
Birth Defects Research (Part A) 82:307 (2008)
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A North American Registry for Epilepsy and Pregnancy, a Unique Public/Private Partnership of Health Surveillance
Epilepsia 1998;39:793-798
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